Recently, I needed a tow vehicle to cover several hundred miles. Unfortunately the local Uhaul only had a 10ft and 26ft moving vans, the next closest depots 20 minutes south of me lacked any pick-ups either, which I knew would be more comfortable and a more capable tow vehicle than a small van. Enterprise does have truck rentals, but the nearest ones with towing kits were located in Milwaukee. So reluctantly, I rented the 10 ft box van, locally with the car hauler.
First impressions were the 6.0L had plenty of power and the transmission worked well in "tow" mode, unfortunately it retained GM's longstanding terrible, nonlinear throttle response. It was a 2018 with 33K miles (less than my Focus, ironically) and the instruments were complete and well laid out, the tach was part of the multi-function display. Unfortunately the perfectly good standard head unit was replaced with a terrible aftermarket one that made simple tuning a PITA. I also found out quickly that the 10 foot van was a mediocre long distance vehicle for a myriad of reasons...
My suspicions were confirmed that despite being a 2018, and a vehicle with a purpose of driving long distance it lacked cruise control. Although reading the wiki it uses a Flexfuel version of an engine debuted in 2007, so it's possible it has a mechanical throttle cable (makes it much costlier to equip it). Still, it wasn't capable of holding a steady speed at one throttle position (because it has bad throttle response I mentioned), so I was constantly slowing and speeding. I was also the wind's bitch, I spent more concentration than should be considered safe keeping the van and trailer in my lane. I expected some, but got far more than that. So that's two marks against the van and in favor of a pick up. The seats also lacked support (I'm 5'11") and my back was sore after a couple hours- I forgot what it's like to drive something with unsupportive seats. The wheel intrusion (inherent in any van, of course), is problematic for lower back/hip alignment, so avoid a van if you have any issues with that (as I do).
A minor issue was the gearing. Surprisingly, it is geared appropriate for the highway, unfortunately at 60-65 it's constantly hunting between 5th and 6th under any kind of load or grade. And yes, I know UHaul recommends "nO ExCeEDinG fIFtY FivE" with their trailers (lol ok). The back-up camera (integrated in the mirror) was also a total joke- it was both tiny and had a horrendously poor resolution, and a range of as little as 20-25 feet. And that's kind of an issue, in a box van. It also had a surprising amount of wind noise, far more than anything I've owned (that had every window).
The last big issue I had with it, is the suspension is incredibly bouncy. And that translates itself into the trailer AND the car on it, which can make things dicey when say.. you're doing 60 mph on the Chicago Skyway at night and there is still plenty of traffic. Makes staying in your lane by no means easier.
Would I do it again? No. Not unless it was a last resort. It's a capable tow vehicle, but far more compromised and less ideal than a modern pick up truck, at least for long distances. If I didn't live in a rural backwater, it would have been foolish and I would have got an enterprise 3/4T truck (1/2ts they said don't get a towing kit), which would have been far cheaper and a vastly more pleasant drive. Also, funnily enough it's been 3-4 years since I actually towed anything until now.
Edit: almost forgot it has NO locking glovebox, which is an issue if you're carrying a ton of cash.
Oh, and if you drive through Indiana they gouge you on the northern toll road and it's filled with these terrifying things. Can I blame Electric Fence Pence for that??